11.3.1 Introduction

Q-Chem can perform hybrid quantum mechanics/molecular mechanics (QM/MM) calculations either as a stand-alone program, which is described in this section, or in conjunction with the Charmm package. ⁵⁴⁵ III H. L. Woodcock et al.
J. Comput. Chem.
(2007), 28, pp. 1485. Link See Section 11.4 for a description of a latter approach.